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AZD6482 (S-isomer) Catalog No : 17011901

Chemical Information

Product NameAZD6482 (S-isomer)
Iupac Chemical Name(S)-2-((1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)amino)benzoic acid 
SynonymsAZD6482 (S); AZD6482; AZD-6482; AZD 6482 
Molecular FormulaC22H24N4O4 
Molecular Weight408.458 
SmileCC=1C=C(C=2N(C(C=C(N2)N2CCOCC2)=O)C1)[C@H](C)NC1=C(C(=O)O)C=CC=C1
InChiKeyIRTDIKMSKMREGO-HNNXBMFYSA-N
InChiInChI=1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m0/s1
Cas1173900-37-2

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

AZD6482 is a potent, selective and ATP competitive PI3K inhibitor (IC(50) 0.01 μm). AZD6482 inhibited insulin-induced human adipocyte glucose uptake in vitro (IC(50) of 4.4 μm). This is the first human target validation for PI3K inhibition as anti-platelet therapy showing a mild and generalized antiplatelet effect attenuating but not completely inhibiting multiple signaling pathways with an impressive separation towards primary hemostasis. AZD6482 at 'supratherapeutic' plasma concentrations may attenuate insulin signaling, most likely through PI3K inhibition. 

Chemical Structure

17011901 - AZD6482 (S-isomer) | CAS 1173900-37-2

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