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ABT-737 Catalog No : 52640

Chemical Information

Product NameABT-737
Molecular FormulaC42H45ClN6O5S2 
Molecular Weight813.43 
SmileCN(C)CCC[[email protected]](CSc1ccccc1)Nc2ccc(cc2[N+](=O)[O-])S(=O)(=O)NC(=O)c3ccc(cc3)N4CCN(CC4)Cc5ccccc5c6ccc(cc6)Cl
InChiKeyFMTXCVYVAOPYBP-PSXMRANNSA-N
InChiInChI=1S/C43H47ClN6O5S2/c1-47(2)24-8-10-36(31-56-38-11-4-3-5-12-38)45-41-23-22-39(29-42(41)50(52)53)57(54,55)46-43(51)33-16-20-37(21-17-33)49-27-25-48(26-28-49)30-34-9-6-7-13-40(34)32-14-18-35(44)19-15-32/h3-7,9,11-23,29,36,45H,8,10,24-28,30-31H2,1-2H3,(H,46,51)/t36-/m1/s1
Cas852808-04-9
MDLMFCD18711683

Technical Data

Purity98% 
Quality control

Description

ABT-737 is a BH3 mimetic inhibitor of Bcl-xLBcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2. 

Chemical Structure

52640 - ABT-737 | CAS 852808-04-9

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