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AM-2394 Catalog No : 16122855

Chemical Information

Product NameAM-2394
Iupac Chemical NameAM-2394 
SynonymsAM 2394; AM2394 
Molecular FormulaC22H25N5O4 
Molecular Weight423.473 
InChiKey
InChi
Cas1442684-77-6

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. 

Chemical Structure

16122855 - AM-2394 | CAS 1442684-77-6

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