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AZD0364 Catalog No : 192275

Chemical Information

Product NameAZD0364
Iupac Chemical Name(6R)-7-(3,4-Difluorobenzyl)-6-(methoxymethyl)-2-{5-methyl-2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl}-6,7-dihydroimidazo[1,2-a]pyrazin-8(5H)-one
SynonymsAZD0364; AZD-0364; AZD 0364.
Molecular FormulaC24H24F2N8O2
Molecular Weight494.5068
SmileO=C1C2=NC(C3=NC(NC4=CC=NN4C)=NC=C3C)=CN2C[[email protected]](COC)N1CC5=CC=C(F)C(F)=C5
InChiKeyHVIGNZUDBVLTLU-MRXNPFEDSA-N
InChiInChI=1S/C24H24F2N8O2/c1-14-9-27-24(30-20-6-7-28-32(20)2)31-21(14)19-12-33-11-16(13-36-3)34(23(35)22(33)29-19)10-15-4-5-17(25)18(26)8-15/h4-9,12,16H,10-11,13H2,1-3H3,(H,27,30,31)/t16-/m1/s1
Cas2097416-76-5

Technical Data

AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
Quality control

Description

AZD0364 is an ERK1 and​/or ERK2 kinase for the treatment of cancer. ERK1 and ERK2 kinases are ubiquitously expressed MAPK kinases that participate in the RAS-​RAF-​MEK-​ERK signalling cascade in the regulation of cell cycle progression, cell proliferation, survival, metab. and transcription.

Chemical Structure

192275 - AZD0364  | CAS 2097416-76-5

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