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AZD3759 Catalog No : 901301

Chemical Information

Product NameAZD3759
Iupac Chemical Name(R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate 
SynonymsAZD-3759;AZD3759;AZD 3759 
Molecular FormulaC22H23ClFN5O3 
Molecular Weight459.90 
SmileCOC1=C(OC(N2[[email protected]](C)CN(C)CC2)=O)C=C3C(N=CN=C3NC4=CC=CC(Cl)=C4F)=C1

Technical Data

Appearanceoff-white solid 
Purity99% by HPLC 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Shipping ConditionShipped under ambient temperature 
Quality control HNMR HPLC


AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. Check for active clinical trials using this agent.


1. Li X, Wang Y, Wang J, Zhang T, Zheng L, Yang Z, Xing L, Yu J.,Enhanced efficacy of AZD3759 and radiation on brain metastasis from EGFR mutant non-small cell lung cancer.Int J Cancer. 2018 Jul 1;143(1):212-224. doi: 10.1002/ijc.31303. Epub 2018 Mar 1.

2. Chao D, Pang L, Shi Y, Wang W, Liu K., AZD3759 induces apoptosis in hepatoma cells by activating a p53-SMAD4 positive feedback loop.Biochem Biophys Res Commun. 2019 Feb 5;509(2):535-540. doi: 10.1016/j.bbrc.2018.12.102. Epub 2018 Dec 28.

Chemical Structure

901301 - AZD3759 | CAS 1626387-80-1


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