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Acolbifene Catalog No : 161227113

Chemical Information

Product NameAcolbifene
Iupac Chemical NameAcolbifene 
SynonymsEM 652; EM-652; EM652; SCH57068; SCH-57068; SCH 57068; Acolbifene 
Molecular FormulaC29H31NO4 
Molecular Weight457.56 
SmileCC1=C(C(Oc2c1ccc(c2)O)c3ccc(cc3)OCCN4CCCCC4)c5ccc(cc5)O
InChiKeyDUYNJNWVGIWJRI-UHFFFAOYSA-N
InChiInChI=1S/C29H31NO4/c1-20-26-14-11-24(32)19-27(26)34-29(28(20)21-5-9-23(31)10-6-21)22-7-12-25(13-8-22)33-18-17-30-15-3-2-4-16-30/h5-14,19,29,31-32H,2-4,15-18H2,1H3
Cas182167-02-8
MDLMFCD00921580

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Acolbifene, also known as EM-652, or SCH-57068, is a selective estrogen receptor modulator (SERM). Acolbifene is currently being studied in the prevention of breast cancer in women at high risk of breast cancer. EM-652 (SCH 57068) and the prodrug EM-800 (SCH57050) which are the most potent of the known antiestrogens. EM-652 is the compound having the highest affinity for the estrogen receptor, including estradiol. It has higher affinity for the ER than ICI 182780, hydroxytamoxifen, raloxifene, droloxifene and hydroxytoremifene. EM-652 has the most potent inhibitory activity on both ER alpha and ER beta compared to any of the other antiestrogens tested. EM-652 was also the most potent inhibitor of the percentage of cycling cancer cells. ( J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):51-84.) 

Chemical Structure

161227113 - Acolbifene | CAS 182167-02-8

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