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Afatinib dimaleate Catalog No : 52762

Chemical Information

Product NameAfatinib dimaleate
Molecular FormulaC32H33ClFN5O11 
Molecular Weight718.08 
SmileCN(C)CCCC(=O)Nc1cc2c(cc1OC3CCOC3)ncnc2Nc4ccc(c(c4)Cl)F.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O
InChiKeyWSWGLYVYONDLQD-SPIKMXEPSA-N
InChiInChI=1S/C24H27ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15;2*5-3(6)1-2-4(7)8/h5-6,10-12,14,16H,3-4,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
Cas850140-73-7
MDLMFCD22581558

Technical Data

Purity98% 
SolubilityDMSO 
Quality control

Description

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. 

Chemical Structure

52762 - Afatinib dimaleate | CAS 850140-73-7

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