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Afatinib Catalog No : 52719

Chemical Information

Product NameAfatinib
Molecular FormulaC24H25ClFN5O3 
Molecular Weight485.94 
SmileCN(C)C/C=C/C(=O)Nc1cc2c(cc1O[[email protected]]3CCOC3)ncnc2Nc4ccc(c(c4)Cl)F
InChiKeyULXXDDBFHOBEHA-CWDCEQMOSA-N
InChiInChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
Cas850140-72-6
MDLMFCD12407405

Technical Data

Purity98% 
SolubilityDMSO ��93mg/mL Water <1.2mg/mL Ethanol ��93mg/mL 
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Description

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. 

Chemical Structure

52719 - Afatinib | CAS 850140-72-6

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