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Afegostat ( Isofagomine D-Tartrate), ethanol solution Catalog No : 161227115

Chemical Information

Product NameAfegostat ( Isofagomine D-Tartrate), ethanol solution
Iupac Chemical NameAfegostat ( Isofagomine D-Tartrate), ethanol solution 
SynonymsAT2101; AT-2101, AT 2101; Isofagomine D-Tartrate; Isofagomine; Afegostat; D-Isofagomine; isoFagomine. brand name: Plicera 
Molecular FormulaC10H19NO9 
Molecular Weight297.26 
SmileC1[[email protected]@H]([[email protected]]([[email protected]@H](CN1)O)O)CO.[[email protected]]([[email protected]@H](C(=O)O)O)(C(=O)O)O
InChiKeyULBPPCHRAVUQMC-AWUBODBRSA-N
InChiInChI=1S/C6H13NO3.C4H6O6/c8-3-4-1-7-2-5(9)6(4)10;5-1(3(7)8)2(6)4(9)10/h4-10H,1-3H2;1-2,5-6H,(H,7,8)(H,9,10)/t4-,5-,6-;1-,2-/m10/s1
Cas957230-65-8
MDLMFCD18252640

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Afegostat, aslo known as Isofagomine D-Tartrate and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid -glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes (N370S and V394L). Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain extracts. Note: Afegostat in pure form is a semisolid. For the convenience of use, this product is supplied as ethanol-water solution (1:1, v/v) with Afegostat concentration 100 mg /mL. 

Chemical Structure

161227115 - Afegostat ( Isofagomine D-Tartrate), ethanol solution | CAS 957230-65-8

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