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Afegostat ( Isofagomine D-Tartrate), ethanol solution Catalog No : 161227115

Chemical Information

Product NameAfegostat ( Isofagomine D-Tartrate), ethanol solution
Iupac Chemical NameAfegostat ( Isofagomine D-Tartrate), ethanol solution 
SynonymsAT2101; AT-2101, AT 2101; Isofagomine D-Tartrate; Isofagomine; Afegostat; D-Isofagomine; isoFagomine. brand name: Plicera 
Molecular FormulaC10H19NO9 
Molecular Weight297.26 
SmileC1[[email protected]@H]([[email protected]]([[email protected]@H](CN1)O)O)CO.[[email protected]]([[email protected]@H](C(=O)O)O)(C(=O)O)O

Technical Data

Appearancecrystalline solid 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control


Afegostat, aslo known as Isofagomine D-Tartrate and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid -glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes (N370S and V394L). Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain extracts. Note: Afegostat in pure form is a semisolid. For the convenience of use, this product is supplied as ethanol-water solution (1:1, v/v) with Afegostat concentration 100 mg /mL. 

Chemical Structure

161227115 - Afegostat ( Isofagomine D-Tartrate), ethanol solution | CAS 957230-65-8


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