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Afuresertib HCl Catalog No : 161227116

Chemical Information

Product NameAfuresertib HCl
Iupac Chemical NameAfuresertib HCl 
SynonymsGSK2110183; GSK 2110183; GSK-2110183; GSK2110183B; GSK 2110183B; GSK2110183B; Afuresertib 
Molecular FormulaC18H18Cl3FN4OS 
Molecular Weight463.78 
InChiKey
InChi
Cas1047645-82-8

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. 

Chemical Structure

161227116 - Afuresertib HCl | CAS 1047645-82-8

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