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Aloxistatin (E-64d) Catalog No : 16122801

Chemical Information

Product NameAloxistatin (E-64d)
Iupac Chemical NameAloxistatin (E-64d) 
SynonymsE-64d; E-64c ethyl ester; Loxistatin; NSC 694281; NSC694281; NSC-694281; EST; EP-453; EP453; EP 453; Aloxistatin 
Molecular FormulaC17H30N2O5 
Molecular Weight342.436 
SmileCCOC(=O)[[email protected]@H]1[[email protected]](O1)C(=O)N[[email protected]@H](CC(C)C)C(=O)NCCC(C)C
InChiKeySRVFFFJZQVENJC-IHRRRGAJSA-N
InChiInChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
Cas88321-09-9
MDLMFCD00132883

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Aloxistatin (E-64d), is a selective cysteine protease inhibitor or calpain and autophagy inhibitor. E-64d prevents in vitro cerulein- induced trypsinogen activation. E-64d can enter the intact cell and inhibit calpain. E-64d has been shown safe for the treatment of Alzheimer's disease in human. E-64d is potentially useful in the treatment of developmental seizure-induced brain damage both by regulating abnormal zinc signal transduction and through the modulation of altered lipid metabolism via ApoE/clusterin pathway in hippocampus. 

Chemical Structure

16122801 - Aloxistatin (E-64d) | CAS 88321-09-9

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