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Argatroban Catalog No : 16122858

Chemical Information

Product NameArgatroban
Iupac Chemical NameArgatroban 
SynonymsMCI-9038; MCI9038; MCI9038; MD805; MD-805; MD 805; MMTQAP; MPQA 
Molecular FormulaC23H36N6O5S 
Molecular Weight508.64 
SmileC[[email protected]@H]1CCN([[email protected]](C1)C(=O)O)C(=O)[[email protected]](CCCNC(=N)N)NS(=O)(=O)c2cccc3c2NCC(C3)C.O
InChiKeyAIEZTKLTLCMZIA-CZSXTPSTSA-N
InChiInChI=1S/C23H36N6O5S.H2O/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19;/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26);1H2/t14-,15?,17+,18-;/m1./s1
Cas141396-28-3
MDLMFCD00895735

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Argatroban is an anticoagulant that is a direct thrombin inhibitor. Argatroban was approved in 2000 for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). Argatroban is a direct thrombin inhibitor that reversibly binds to the thrombin active site. Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; activation of protein C; and platelet aggregation. Argatroban inhibits thrombin with an inhibition constant (Ki) of 0.04 M. 

Chemical Structure

16122858 - Argatroban | CAS 141396-28-3

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