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BAZ2-ICR Catalog No : 111907

Chemical Information

Product NameBAZ2-ICR
Synonyms4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]-benzonitrile 
Molecular FormulaC20H19N7 
Molecular Weight357.4 
SmileCN1C=C(CCN2C=NC(C3=CN(C)N=C3)=C2C4=CC=C(C#N)C=C4)C=N1
InChiKeyRRZVGDGTWNQAPW-UHFFFAOYSA-N
InChiInChI=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24-26(2)13-18)20(27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3
Cas1665195-94-7

Technical Data

AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

BAZ2-ICR is a small molecule inhibitor of BAZ2A (Kd = 109 nM; IC50 = 130 nM) and BAZ2B (Kd = 170 nM; IC50 = 180 nM) bromodomains. It demonstrates 15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. 

Chemical Structure

111907 - BAZ2-ICR | CAS 1665195-94-7

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