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BIX 02189 Catalog No : 111912

Chemical Information

Product NameBIX 02189
Iupac Chemical Name(Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide 
SynonymsBIX02189; BIX-02189 
Molecular FormulaC27H28N4O2 
Molecular Weight440.53682 
SmileO=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=CC(CN(C)C)=C3)/C4=CC=CC=C4)N(C)C
InChiKeyHOMJAAIVTDVQJA-IZHYLOQSSA-N
InChiInChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,28H,17H2,1-4H3,(H,29,32)/b25-24-
Cas1265916-41-3

Technical Data

AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM, which was reported to inhibit catalytic function of purified, MEK5 enzyme. 

Chemical Structure

111912 - BIX 02189 | CAS 1265916-41-3

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