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BMS-816336 Catalog No : 19351

Chemical Information

Product NameBMS-816336
Iupac Chemical Name2-((1R,2R,3S,5R,6R)-6-hydroxy-2-phenyladamantan-2-yl)-1-(3-hydroxyazetidin-1-yl)ethan-1-one
SynonymsBMS-816336; BMS 816336; BMS816336.
Molecular FormulaC21H27NO3
Molecular Weight341.451
SmileOC1CN(C(C[[email protected]]2(C3=CC=CC=C3)[[email protected]]4C[[email protected]@H]5[[email protected]@H](O)C(C4)C[[email protected]]2C5)=O)C1
InChiKeyOAAZMUGLOXGVNH-MEMOLBONSA-N, OAAZMUGLOXGVNH-CCVYDFRESA-N
InChiInChI=1S/C21H27NO3/c23-18-11-22(12-18)19(24)10-21(15-4-2-1-3-5-15)16-6-13-7-17(21)9-14(8-16)20(13)25/h1-5,13-14,16-18,20,23,25H,6-12H2/t13-,14?,16-,17+,20-,21-/m1/s1
Cas1009583-20-3

Technical Data

AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
Quality control

Description

BMS-816336 is an orally active, potent and selective 11β-HSD1 inhibitor. BMS-816336 showed activity against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme (IC50 3.0 nM) with >10000 fold selectivity over human 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2).

Chemical Structure

19351 - BMS-816336  | CAS 1009583-20-3

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