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Briciclib Catalog No : 611917

Chemical Information

Product NameBriciclib
Iupac Chemical NameBriciclib 
SynonymsON-014185; ON014185; ON 014185 
Molecular FormulaC19H23O10PS 
Molecular Weight474.42 
SmileCOc1ccc(cc1OP(=O)(O)O)CS(=O)(=O)/C=C/c2c(cc(cc2OC)OC)OC
InChiKeyLXENKEWVEVKKGV-BQYQJAHWSA-N
InChiInChI=1S/C19H23O10PS/c1-25-14-10-17(27-3)15(18(11-14)28-4)7-8-31(23,24)12-13-5-6-16(26-2)19(9-13)29-30(20,21)22/h5-11H,12H2,1-4H3,(H2,20,21,22)/b8-7+
Cas865783-99-9
MDLMFCD22665751

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells.


Briciclib inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at nanomolar concentrations (GI50 = 9.8 - 12.2 nM).  Cyclin D1 is a protein required for normal progression through the cell cycle and is overexpressed in many tumors. Cyclin D1 expression is regulated through a process termed cap-dependent translation, which requires the function of eukaryotic initiation factor 4E (eIF4E) protein. In vitro evidence indicates that briciclib binds to eIF4E, blocking cap-dependent translation of cyclin D1 and other cancer proteins (c-MYC, VEGF), leading to tumor cell death. Briciclib is potent and shown to be active in nonclinical tumor models when combined with several chemotherapeutics.


 

Chemical Structure

611917 - Briciclib | CAS 865783-99-9

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