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Daprodustat Catalog No : 17030716

Chemical Information

Product NameDaprodustat
Iupac Chemical Name(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine 
SynonymsGSK1278863; GSK 1278863; GSK-1278863; Daprodustat 
Molecular FormulaC19H27N3O6 
Molecular Weight393.44 
SmileC1(CCCCC1)N1C(N(C(C(C1=O)C(=O)NCC(=O)O)=O)C1CCCCC1)=O
InChiKeyRUEYEZADQJCKGV-UHFFFAOYSA-N
InChiInChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)
Cas960539-70-2

Technical Data

Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Daprodustat, also known as GSK1278863, is a novel HIF-prolyl hydroxylase inhibitor. Hypoxia inducible factor (HIF) stabilization by HIF-prolyl hydroxylase (PHD) inhibitors may improve ischemic conditions such as peripheral artery disease (PAD). Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease. 

Chemical Structure

17030716 - Daprodustat | CAS 960539-70-2

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