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G007-LK Catalog No : 62908

Chemical Information

Product NameG007-LK
Iupac Chemical Name(E)-4-(5-(2-(4-(2-chlorophenyl)-5-(5-(methylsulfonyl)pyridin-2-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)benzonitrile 
SynonymsG007LK,G007 LK. 
Molecular FormulaC25H16ClN7O3S 
Molecular Weight529.96 
SmileClC1=C(C=CC=C1)N1C(=NN=C1C1=NC=C(C=C1)S(=O)(=O)C)/C=C/C1=NN=C(O1)C1=CC=C(C#N)C=C1
InChiKeyHIWVLHPKZNBSBE-OUKQBFOZSA-N
InChiInChI=1S/C25H16ClN7O3S/c1-37(34,35)18-10-11-20(28-15-18)24-31-29-22(33(24)21-5-3-2-4-19(21)26)12-13-23-30-32-25(36-23)17-8-6-16(14-27)7-9-17/h2-13,15H,1H3/b13-12+
Cas1380672-07-0

Technical Data

Appearancecrystalline solid 
Purity>98% by HPLC 
Solubility5mg/ml in DMSO 
Storage-20ºC for 2 years 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

G007-LK is specific tankyrase 1/2 inhibitor.G007-LK (66) displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50-values of 46 nM and 25 nM, respectively and a cellular IC50-value of 50 nM combined with an excellent pharmacokinetic profile in mice. G007-LK had good oral availability in mice and about a three-hour half-life when administered intravenously, suggesting the compound was sufficiently stable to be a drug candidate.

 

Chemical Structure

62908 - G007-LK | CAS 1380672-07-0

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