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GDC-0810(Brilanestrant,ARN-810) Catalog No : 90731

Chemical Information

Product NameGDC-0810(Brilanestrant,ARN-810)
Iupac Chemical Name(E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid 
SynonymsBrilanestrant;GDC-0810;GDC 0810;GDC0810;ARN-810;ARN 810;ARN810 
Molecular FormulaC26H20ClFN2O2 
Molecular Weight446.90 
SmileO=C(O)/C=C/C1=CC=C(/C(C2=CC3=C(NN=C3)C=C2)=C(C4=CC=C(F)C=C4Cl)/CC)C=C1
InChiKeyBURHGPHDEVGCEZ-KJGLQBJMSA-N
InChiInChI=1S/C26H20ClFN2O2/c1-2-21(22-10-9-20(28)14-23(22)27)26(18-8-11-24-19(13-18)15-29-30-24)17-6-3-16(4-7-17)5-12-25(31)32/h3-15H,2H2,1H3,(H,29,30)(H,31,32)/b12-5+,26-21+
Cas1365888-06-7

Technical Data

Appearancecrystalline solid 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

GDC-0810 (Brilanestrant, ARN-810, RG6046) is a selective estrogen receptor degrader (SERD) that is designed to bind to the estrogen receptor to limit its function. In addition, when SERDs bind to the estrogen receptor, they may be able to change the shape of the receptor in such a way that the cell eliminates it by degradation.

Mechanism of Action / Target

Selective estrogen receptor degrader

 

Chemical Structure

90731 - GDC-0810(Brilanestrant,ARN-810) | CAS 1365888-06-7

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