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GDC-0941 Catalog No : 120115

Chemical Information

Product NameGDC-0941
Iupac Chemical Name4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine 
SynonymsGDC 0941; GDC0941; RG7321; RG-7321; RG 7321; GNE0941; GNE-0941; GNE 0941; Pictrelisib 
Molecular FormulaC23H27N7O3S2 
Molecular Weight513.636 
SmileCS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6
InChiKeyLHNIIDJUOCFXAP-UHFFFAOYSA-N
InChiInChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
Cas957054-30-7

Technical Data

AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

GDC-0941 is a potent inhibitor of PI3K/ with IC50 of 3 nM, with modest selectivity against p110 (11-fold) and p110 (25-fold). 

Chemical Structure

120115 - GDC-0941 | CAS 957054-30-7

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