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GNE-272 Catalog No : 20178121

Chemical Information

Product NameGNE-272
Iupac Chemical Name(S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one 
SynonymsGNE-272;GNE 272;GNE272 
Molecular FormulaC22H25FN6O2 
Molecular Weight424.4804 
SmileFC1=C(C=CC(=C1)C=1C=NN(C1)C)NC1=NN(C2=C1CN(CC2)C(C)=O)[[email protected]@H]2COCC2
InChiKeyNKOJNOBJGYTLLZ-KRWDZBQOSA-N
InChiInChI=1S/C22H25FN6O2/c1-14(30)28-7-5-21-18(12-28)22(26-29(21)17-6-8-31-13-17)25-20-4-3-15(9-19(20)23)16-10-24-27(2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)/t17-/m0/s1
Cas1936428-93-1

Technical Data

Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

GNE-272 is a potent and selective in Vivo Probe for the Bromodomains of CBP/EP300 (CBP IC50 = 0.02 M, EP300 IC50 = 0.03 M, BRET IC50 = 0.41 M, BRD4(1) C50 = 13 M). 

Chemical Structure

20178121 - GNE-272 | CAS 1936428-93-1

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