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GNF-5 Catalog No : 52216

Chemical Information

Product NameGNF-5
Iupac Chemical NameN-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide 
SynonymsGNF-5 
Molecular FormulaC20H17F3N4O3 
Molecular Weight418.37 
SmileO=C(NCCO)C1=CC=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=C1
InChiKeyIIQUYGWWHIHOCF-UHFFFAOYSA-N
InChiInChI=1S/C20H17F3N4O3/c21-20(22,23)30-16-6-4-15(5-7-16)27-18-11-17(25-12-26-18)13-2-1-3-14(10-13)19(29)24-8-9-28/h1-7,10-12,28H,8-9H2,(H,24,29)(H,25,26,27)
Cas778277-15-9

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.220.1 uM (Wild type Abl) 

Chemical Structure

52216 - GNF-5 | CAS 778277-15-9

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