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GSK2334470 Catalog No : 192224

Chemical Information

Product NameGSK2334470
Iupac Chemical Name(3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl)-N-cyclohexyl-6-methylpiperidine-3-carboxamide
SynonymsGSK2334470; GSK 2334470; GSK-2334470
Molecular FormulaC25H34N8O
Molecular Weight462.59
SmileO=C([[email protected]@H]1CN(C2=NC(NC)=NC(C3=CC4=C(C=C3)C(N)=NN4)=C2)[[email protected]](C)CC1)NC5CCCCC5
InChiKeyQLPHOXTXAKOFMU-WBVHZDCISA-N
InChiInChI=1S/C25H34N8O/c1-15-8-9-17(24(34)28-18-6-4-3-5-7-18)14-33(15)22-13-20(29-25(27-2)30-22)16-10-11-19-21(12-16)31-32-23(19)26/h10-13,15,17-18H,3-9,14H2,1-2H3,(H,28,34)(H3,26,31,32)(H,27,29,30)/t15-,17+/m1/s1
Cas1227911-45-6

Technical Data

AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
Quality control

Description

GSK2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM), which does not suppress the activity of 93 other protein kinases including 13 AGC-kinases most related to PDK1 at 500-fold higher concentrations.

Chemical Structure

192224 - GSK2334470  | CAS 1227911-45-6

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