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GSK2636771 Catalog No : 52618

Chemical Information

Product NameGSK2636771
Iupac Chemical Name2-methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid 
SynonymsGSK-2636771,GSK 2636771 
Molecular FormulaC22H22F3N3O3 
Molecular Weight433.42 
SmileCC1=NC2=C(N1CC1=C(C(=CC=C1)C(F)(F)F)C)C=C(C=C2C(=O)O)N2CCOCC2
InChiKeyXTKLTGBKIDQGQL-UHFFFAOYSA-N
InChiInChI=1S/C22H22F3N3O3/c1-13-15(4-3-5-18(13)22(23,24)25)12-28-14(2)26-20-17(21(29)30)10-16(11-19(20)28)27-6-8-31-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3,(H,29,30)
Cas1372540-25-4

Technical Data

Appearancesolid 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

GSK2636771 is a potent, orally bioavailable and selective inhibitor of PI3K (0.89 nM), with >900-fold selectivity over PI3K/PI3K and >10-fold over PI3K. It inhibits AKT phosphorylation and downstream signalling measured as decrease of PRAS40-, GSK3-, and RPS6-phosphorylation in PTEN mutant cell lines.

 

Chemical Structure

52618 - GSK2636771 | CAS 1372540-25-4

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