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GSK321 Catalog No : 2017821

Chemical Information

Product NameGSK321
Iupac Chemical Name(R)-1-(4-Fluorobenzyl)-N-(3-((S)-1-hydroxyethyl)phenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide 
SynonymsGSK321|GSK 321|GSK-321 
Molecular FormulaC28H28FN5O3 
Molecular Weight501.5624 
SmileFC1=CC=C(CN2N=C(C=3CN(C[[email protected]](C32)C)C(=O)C=3NC=CC3)C(=O)NC3=CC(=CC=C3)[[email protected]](C)O)C=C1
InChiKeyIVFDDVKCCBDPQZ-MSOLQXFVSA-N
InChiInChI=1S/C28H28FN5O3/c1-17-14-33(28(37)24-7-4-12-30-24)16-23-25(27(36)31-22-6-3-5-20(13-22)18(2)35)32-34(26(17)23)15-19-8-10-21(29)11-9-19/h3-13,17-18,30,35H,14-16H2,1-2H3,(H,31,36)/t17-,18+/m1/s1
Cas1816331-63-1

Technical Data

Appearanceoff-white solid 
Purity98.0% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

GSK321 is a potent and selective IDH1 mutant inhibitor. GSK321 potently inhibited intracellular 2-HG production in HT-1080 cells, with a half-maximal effective concentration (EC50) of 85 nM by LC/MS/MS analysis. 

Chemical Structure

2017821 - GSK321 | CAS 1816331-63-1

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