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GSKJ1 Catalog No : 191255

Chemical Information

Product NameGSKJ1
Iupac Chemical Name3-((2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)pyrimidin-4-yl)amino)propanoic acid
SynonymsGSKJ1; GSKJ 1; GSKJ-1.
Molecular FormulaC22H23N5O2
Molecular Weight389.459
SmileO=C(O)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC4=CC=CC=C4CC3)=C1
InChiKeyAVZCPICCWKMZDT-UHFFFAOYSA-N
InChiInChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26)
Cas1373422-53-7

Technical Data

AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
Quality control

Description

GSKJ1 is a selective and potent histone demethylase inhibitor (GSK-J1) that has significant activity (IC50 60 nM for human JmjD3) in vitro and in cells using an ester derivative (GSK-J4: 1 µM < IC50 < 10 µM; e.g. 9 µM in primary human macrophages).

Chemical Structure

191255 - GSKJ1 | CAS 1373422-53-7

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