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GW 627368 Catalog No : 91003

Chemical Information

Product NameGW 627368
Synonyms4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide 
Molecular FormulaC30H28N2O6S 
Molecular Weight544.6 
SmileCCOc1c2ccccc2c(c3c1CN(C3=O)c4ccc(cc4)CC(=O)NS(=O)(=O)c5ccccc5)OCC
InChiKeyXREWXJVMYAXCJV-UHFFFAOYSA-N
InChiInChI=1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35,36)22-10-6-5-7-11-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33)
Cas439288-66-1
MDLMFCD12912327

Technical Data

AppearanceCrystalline Solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for human EP4 and TP receptors with Ki values of 100 nM and 158 nM, respectively. Affinity for all other human prostanoid receptors is >5.0 M. In human washed platelets, GW 627368X produced 100% inhibition of U-46619 (EC100)-induced aggregation at a concentration of 10 M. 

Chemical Structure

91003 - GW 627368 | CAS 439288-66-1

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