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HLCL-61 Catalog No : 16062204

Chemical Information

Product NameHLCL-61
Iupac Chemical Name1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride 
SynonymsHLCL 61; HLCL-61. 
Molecular FormulaC23H25ClN2O 
Molecular Weight380.916 
SmileCl.C(C)N1C2=CC=CC=C2C=2C=C(C=CC12)CNCC1=C(C=CC=C1)OC
InChiKeyXYAVCNMZZKTEGR-UHFFFAOYSA-N
InChiInChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
Cas586395-74-6

Technical Data

AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

 HLCL-61 is a potent and selective PRMT5 inhibitor for treatment of acute myeloid leukemia. HLCL-61 resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML (acute myeloid leukemia) cells. As a result, significant antileukemic activity was achieved. The increased PRMT5 activity enhanced AML growth in vitro and in vivo while PRMT5 downregulation reduced it. In AML cells, PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3. 

Chemical Structure

16062204 - HLCL-61 | CAS 586395-74-6

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