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NMS-P118 Catalog No : 17101311

Chemical Information

Product NameNMS-P118
SynonymsNMS-P118; NMS-P 118; NMS P118
Molecular FormulaC20H24F3N3O2
Molecular Weight395.43
SmileO=C(C1=CC(F)=CC(CN2C3CCN(C4CCC(F)(F)CC4)CC3)=C1C2=O)N
InChiKeyARYVAQSYRLZVQD-UHFFFAOYSA-N
InChiInChI=1S/C20H24F3N3O2/c21-13-9-12-11-26(19(28)17(12)16(10-13)18(24)27)15-3-7-25(8-4-15)14-1-5-20(22,23)6-2-14/h9-10,14-15H,1-8,11H2,(H2,24,27)
Cas1262417-51-5

Technical Data

Appearanceo
Purity>98%
SolubilitySoluble in DMSO, not in water
Storage3 years -20ºCpowder
Shipping ConditionShipped under ambient temperature
Quality control

Description

NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor with excellent ADME and pharmacokinetic profiles and high efficacy in vivo both as a single agent and in combination with Temozolomide in MDA-MB-436 and Capan-1 xenograft models, respectively.

Chemical Structure

17101311 - NMS-P118 | CAS 1262417-51-5

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