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Netarsudil(Mesylate) Catalog No : 712181

Chemical Information

Product NameNetarsudil(Mesylate)
Iupac Chemical Name(S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dimethanesulfonate
SynonymsAR-13324; AR13324; AR 13324; Netarsudil Mesylate
Molecular FormulaC30H35N3O9S2
Molecular Weight645.74
SmileCS(=O)(O)=O.CS(=O)(O)=O.O=C(OCC1=CC=C([[email protected]@H](CN)C(NC2=CC3=C(C=NC=C3)C=C2)=O)C=C1)C4=CC=C(C)C=C4C

Technical Data

Appearancelight-yellow solid to off-white solid 
PurityHPLC>99%; Chiral HPLC EE>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature as non-hazardous chemical.
Quality control HNMR HPLC MS COA


Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and​/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.

Chemical Structure

712181 - Netarsudil(Mesylate) | CAS 1422144-42-0


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