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OF-1 Catalog No : 17030904

Chemical Information

Product NameOF-1
Iupac Chemical Name4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide 
SynonymsOF-1; OF1; OF 1 
Molecular FormulaC17H18BrN3O4S 
Molecular Weight440.312 
SmileBrC1=CC(=C(C=C1)S(=O)(=O)NC1=CC2=C(N(C(N2C)=O)C)C=C1OC)C
InChiKeyYUNQZQREIHWDQT-UHFFFAOYSA-N
InChiInChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23,24)19-12-8-13-14(9-15(12)25-4)21(3)17(22)20(13)2/h5-9,19H,1-4H3
Cas19973-83-4

Technical Data

Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

OF-1 is a chemical probe for BRPF bromodomains. OF-1 has been shown to bind to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 uM (ITC). Selectivity against other bromodomains is very good, in general >100-fold. The closest off-target effects are against BRD4 (39-fold selectivity) and TIF1a (50% inhibition at 20 M in the alphascreen).

Chemical Structure

17030904 - OF-1 | CAS 19973-83-4

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