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OICR-9429 Catalog No : 6111010

Chemical Information

Product NameOICR-9429
Iupac Chemical NameOICR-9429 
SynonymsOICR9429, OICR 9429 
Molecular FormulaC29H32F3N5O3 
Molecular Weight555.59 
InChiKey
InChi
Cas1801787-56-3

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction with IC50 of 5 uM. inhibit proliferation and induce differentiation . target: Wdr5 IC 50: 5 uM In vitro: OICR-9429 inhibit proliferation and induce differentiation in p30-expressing human AML cells. OICR-9429 cause a significant decrease in viability in the majority of patient cells with mutations in the N-terminal part of the CEBPA gene. OICR-9429 displays exquisite cellular selectivity and specificity in disrupting critical protein-protein interactions between WDR5. [1] reduce the viability of primary human AML cells with N-terminal C/EBP mutations by about 50% (mean value, n = 8) at 5 M [2] In vivo:The reference for OICR-9429 to mice (female NOD-SCID) is 3 mg/kg. 

Chemical Structure

6111010 - OICR-9429 | CAS 1801787-56-3

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