Shipped under ambient temperature as non-hazardous chemical.
OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction with IC50 of 5 uM. inhibit proliferation and induce differentiation . target: Wdr5 IC 50: 5 uM In vitro: OICR-9429 inhibit proliferation and induce differentiation in p30-expressing human AML cells. OICR-9429 cause a significant decrease in viability in the majority of patient cells with mutations in the N-terminal part of the CEBPA gene. OICR-9429 displays exquisite cellular selectivity and specificity in disrupting critical protein-protein interactions between WDR5.  reduce the viability of primary human AML cells with N-terminal C/EBP mutations by about 50% (mean value, n = 8) at 5 M  In vivo:The reference for OICR-9429 to mice (female NOD-SCID) is 3 mg/kg.
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