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ON 146040 Catalog No : 611901

Chemical Information

Product NameON 146040
Iupac Chemical NameLY3023414 
SynonymsON-146040; ON146040 
Molecular FormulaC24H23N7O3S 
Molecular Weight489.55 
InChiKey
InChi
Cas1404231-34-0

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways; inhibits PI3K / isoforms with IC50 of 14/20 nM. 


ON 146040 was highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1,000 nM range. In biochemical testing, ON 146040 inhibited PI3K / isoforms (IC50 14 and 20 nM, respectively) without having a major effect on / isoforms (IC50 3 and 1 M, respectively). ON 146040 was also found to inhibit Abl1 and several mutant versions of this kinase (IC50 < 150 nM), although the compound was not found to be active against the T315I mutant. Following treatment with ON 146040, STAT3 and STAT5 phosphorylation were down-regulated in leukemia and myeloma cells.


 

Chemical Structure

611901 - ON 146040 | CAS 1404231-34-0

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