Shipped under ambient temperature as non-hazardous chemical.
ONO-4059 is a selective and novel inhibitor of BTK with IC50 2.2 nm, ONO-4059 binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.
BTK is potently inhibited by ONO/GS-4059 with a 50% inhibitory concentration of 2 nmol/L. ONO -4059 induces classical apoptosis at nanomolar concentrations in the activated B-cell diffuse large B-cell lymphoma (DLBCL) cell line, TMD-822 and in a TMD-8 xenograft model, treatment with ONO -4059 resulted in inhibition of tumor growth.
Sun-shine Bio-tech provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs, building blocks and Natural compounds for laboratory and scientific use.