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ONO-4059 hydrochloride Catalog No : 17012103

Chemical Information

Product NameONO-4059 hydrochloride
Iupac Chemical NameONO-4059 hydrochloride 
SynonymsONO4059 hydrochloride; ONO 4059 hydrochloride; GS4059 hydrochloride; GS 4059 hydrochloride; GS-4059 hydrochloride 
Molecular FormulaC₂₅H₂₃ClN₆O₃ 
Molecular Weight490.94 
InChiKey
InChi
Cas1439901-97-9

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

ONO-4059 is a selective and novel inhibitor of BTK with IC50 2.2 nm, ONO-4059 binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

BTK is potently inhibited by ONO/GS-4059 with a 50% inhibitory concentration of 2 nmol/L. ONO -4059 induces classical apoptosis at nanomolar concentrations in the activated B-cell diffuse large B-cell lymphoma (DLBCL) cell line, TMD-822 and in a TMD-8 xenograft model, treatment with ONO -4059 resulted in inhibition of tumor growth.

 

Chemical Structure

17012103 - ONO-4059 hydrochloride | CAS 1439901-97-9

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