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ONO-4059(Tirabrutinib) Catalog No : S032401

Chemical Information

Product NameONO-4059(Tirabrutinib)
Iupac Chemical Name(R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7H-purin-8(9H)-one 
SynonymsONO4059;ONO-4059;ONO 4059;Tirabrutinib 
Molecular FormulaC25H22N6O3 
Molecular Weight454.48 
SmileO=C1N(C2=CC=C(OC3=CC=CC=C3)C=C2)C4=C(N)N=CN=C4N1[[email protected]]5CN(C(C#CC)=O)CC5
InChiKeySEJLPXCPMNSRAM-GOSISDBHSA-N
InChiInChI=1S/C25H22N6O3/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28)/t18-/m1/s1
Cas1439901-97-9(HCl);1351636-18-4(base)

Technical Data

Appearancewhite solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control HNMR

Description

Tirabrutinib(ONO-4059) is a highly potent and selective oral BTK inhibitor. ONO-4059 has demonstrated anti-tumour activity in pre-clinical models (Yasuhiro et al, AACR 2013) and in the clinic in both NHL and CLL patients (Salles et al, ASH 2013; Rule et al, ASH 2013).

 

Chemical Structure

S032401 - ONO-4059(Tirabrutinib) | CAS 1439901-97-9(HCl);1351636-18-4(base)

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