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Omapatrilat Catalog No : 17030903

Chemical Information

Product NameOmapatrilat
Iupac Chemical Name(4S,7S,10aS)-4-((S)-2-mercapto-3-phenylpropanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid 
SynonymsBMS 186716; BMS-186716; BMS186716; Vanlev; Omapatrilat 
Molecular FormulaC19H24N2O4S2 
Molecular Weight408.5349 
SmileS[[email protected]](C(=O)N[[email protected]@H]1C(N2[[email protected]@H](SCC1)CCC[[email protected]]2C(=O)O)=O)CC2=CC=CC=C2
InChiKeyLVRLSYPNFFBYCZ-VGWMRTNUSA-N
InChiInChI=1S/C19H24N2O4S2/c22-17(15(26)11-12-5-2-1-3-6-12)20-13-9-10-27-16-8-4-7-14(19(24)25)21(16)18(13)23/h1-3,5-6,13-16,26H,4,7-11H2,(H,20,22)(H,24,25)/t13-,14-,15-,16-/m0/s1
Cas167305-00-2

Technical Data

Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Omapatrilat is a novel antihypertensive agent that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme. NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling. The drug was promoted for possible uses in congestive heart failure. 

Chemical Structure

17030903 - Omapatrilat | CAS 167305-00-2

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