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Omipalisib(GSK2126458,GSK458) Catalog No : 121429

Chemical Information

Product NameOmipalisib(GSK2126458,GSK458)
Iupac Chemical Name2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)pyridin-3-yl]benzenesulfonamide
SynonymsOmipalisib;GSK-458;GSK-2126458;GSK458;GSK 2126458
Molecular FormulaC25H17F2N5O3S
Molecular Weight505.496
SmileFC1=C(C=CC(=C1)F)S(=O)(=O)NC=1C(=NC=C(C1)C=1C=C2C(=CC=NC2=CC1)C1=CN=NC=C1)OC
InChiKeyCGBJSGAELGCMKE-UHFFFAOYSA-N
InChiInChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3
Cas1086062-66-9

Technical Data

AppearanceSolid powder
Purity98%
SolubilitySoluble in DMSO
Storage-20 ℃ for 3 years
Shipping ConditionShipped under ambient temperature
Quality control

Description

GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively.

Chemical Structure

121429 - Omipalisib(GSK2126458,GSK458) | CAS 1086062-66-9

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