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PTI-428(PTI428) Catalog No : 193211

Chemical Information

Product NamePTI-428(PTI428)
Iupac Chemical NameN-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide, N-(trans-3-(5-((R)-1-hydroxyethyl)-1,3,4-oxadiazol-2-yl)cyclobutyl)-3-phenylisoxazole-5-carboxamide
SynonymsPTI-428, PTI428
Molecular FormulaC18H18N4O4
Molecular Weight 354.36
SmileO=C(C1=CC(C2=CC=CC=C2)=NO1)N[[email protected]]3C[[email protected]](C4=NN=C([[email protected]](O)C)O4)C3
InChiKeyXPEHHUISIBFLHX-RAIGVLPGSA-N
InChiInChI=1S/C18H18N4O4/c1-10(23)17-20-21-18(25-17)12-7-13(8-12)19-16(24)15-9-14(22-26-15)11-5-3-2-4-6-11/h2-6,9-10,12-13,23H,7-8H2,1H3,(H,19,24)/t10-,12-,13-/m1/s1
Cas1953130-87-4

Technical Data

AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO, not in water
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature 
Quality control

Description

PTI-428 is a type of CFTR modulator called an amplifier. Amplifiers increase the amount of CFTR protein in the cell. This makes more CFTR protein available for other therapies, such as ivacaftor and lumacaftor, to work on. When combined with other therapies, PTI-428 may increase CFTR function across multiple gene mutations.

Chemical Structure

193211 - PTI-428(PTI428) | CAS 1953130-87-4

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