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Q-VD-OPH Catalog No : 16071010

Chemical Information

Product NameQ-VD-OPH
Iupac Chemical Name(3S)-5-(2,6-Difluorophenoxy)-3-[[(2S)-3-Methyl-1-oxo-2-[(2-quinolinylcarbonyl)aMino]butyl]aMino]-4-oxo-pentanoic Acid 
SynonymsQ-VD-OPH 
Molecular FormulaC26H25F2N3O6 
Molecular Weight513.8 
SmileFC1=C(OCC([[email protected]](CC(=O)O)NC([[email protected]](C(C)C)NC(=O)C2=NC3=CC=CC=C3C=C2)=O)=O)C(=CC=C1)F
InChiKeyOOBJCYKITXPCNS-REWPJTCUSA-N
InChiInChI=1S/C26H25F2N3O6/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34)/t20-,23-/m0/s1
Cas1135695-98-5

Technical Data

AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). It protects neurotoxin-insulted neurons from apoptotic death, as well as displays minimal toxicity. In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated. 

Chemical Structure

16071010 - Q-VD-OPH | CAS 1135695-98-5

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