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Quizartinib Catalog No : 82703

Chemical Information

Product NameQuizartinib
Iupac Chemical NameN-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride 
SynonymsAC-220; AC220 
Molecular FormulaC29H32N6O4S 
Molecular Weight560.67 
SmileCl.Cl.C(C)(C)(C)C1=CC(=NO1)NC(=O)NC1=CC=C(C=C1)C=1N=C2SC3=C(N2C1)C=CC(=C3)OCCN3CCOCC3
InChiKeyDHYPGRVMIOATAE-UHFFFAOYSA-N
InChiInChI=1S/C29H32N6O4S.2ClH/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34;;/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36);2*1H
Cas950769-58-1

Technical Data

AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

Quizartinib is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFR_alpha_, PDGFR_beta_, RET, and CSF-1R. 

Chemical Structure

82703 - Quizartinib | CAS 950769-58-1

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