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R-GNE-140 Catalog No : 18432

Chemical Information

Product NameR-GNE-140
Iupac Chemical Name(R)-3-((2-Chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one
SynonymsR-GNE-140; (R)-GNE-140; GNE 140; GNE140.
Molecular FormulaC25H23ClN2O3S2
Molecular Weight499.04
SmileO=C1C(SC2=CC=CC=C2Cl)=C(O)C[[email protected]](C3=CSC=C3)(C4=CC=C(N5CCOCC5)C=C4)N1
InChiKeySUFXXEIVBZJOAP-RUZDIDTESA-N
InChiInChI=1S/C25H23ClN2O3S2/c26-20-3-1-2-4-22(20)33-23-21(29)15-25(27-24(23)30,18-9-14-32-16-18)17-5-7-19(8-6-17)28-10-12-31-13-11-28/h1-9,14,16,29H,10-13,15H2,(H,27,30)/t25-/m1/s1
Cas2003234-63-5

Technical Data

AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO, not in water
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
Quality control

Description

R-GNE-140 a novel potent lactate dehydrogenase (LDHA) inhibitor with IC50 3nM for LDHA and 5 nM for LDHB.

Chemical Structure

18432 - R-GNE-140 | CAS 2003234-63-5

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