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R788 (Fostamatinib) Disodium Catalog No : 51609

Chemical Information

Product NameR788 (Fostamatinib) Disodium
Iupac Chemical Name2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, sodium salt (1:2) 
SynonymsN/A 
Molecular FormulaC23H24FN6O9P.2Na 
Molecular Weight624.42 
SmileCC1(C(=O)N(c2c(ccc(n2)Nc3c(cnc(n3)Nc4cc(c(c(c4)OC)OC)OC)F)O1)COP(=O)([O-])[O-])C.[Na+].[Na+]
InChiKeyHSYBQXDGYCYSGA-UHFFFAOYSA-L
InChiInChI=1S/C23H26FN6O9P.2Na/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29);;/q;2*+1/p-2
Cas1025687-58-4
MDLMFCD15146370

Technical Data

Purity98% 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Quality control

Description

R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3. 

Chemical Structure

51609 - R788 (Fostamatinib) Disodium | CAS 1025687-58-4

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