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Rigosertib (ON-01910) Catalog No : 52010

Chemical Information

Product NameRigosertib (ON-01910)
Iupac Chemical NameN-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium salt]phenyl]-glycine,sodium salt (1:1) 
SynonymsRigosertib,ON-01910 
Molecular FormulaC21H24NNaO8S 
Molecular Weight473.47 
SmileCOc1ccc(cc1NCC(=O)[O-])CS(=O)(=O)/C=C/c2c(cc(cc2OC)OC)OC.[Na+]
InChiKeyVLQLUZFVFXYXQE-USRGLUTNSA-M
InChiInChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
Cas1225497-78-8
MDLMFCD11655911

Technical Data

Appearanceoff-white solid 
Purity98% 
Solubility50mg/ml in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Phase 3. 

Chemical Structure

52010 - Rigosertib (ON-01910) | CAS 1225497-78-8

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