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SHP394 Catalog No : 193122

Chemical Information

Product NameSHP394
Iupac Chemical Name6-amino-2-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-methyl-5-((2-(trifluoromethyl)pyridin-3-yl)thio)pyrimidin-4(3H)-one
SynonymsSHP394; SHP-394; SHP 394;
Molecular FormulaC20H25F3N6O2S
Molecular Weight470.5152
SmileO=C1N(C)C(N(CC2)CCC32[[email protected]](N)[[email protected]](C)OC3)=NC(N)=C1SC4=CC=CN=C4C(F)(F)F
InChiKeyQZHZIDHAIVAHMD-SMDDNHRTSA-N
InChiInChI=1S/C20H25F3N6O2S/c1-11-14(24)19(10-31-11)5-8-29(9-6-19)18-27-16(25)13(17(30)28(18)2)32-12-4-3-7-26-15(12)20(21,22)23/h3-4,7,11,14H,5-6,8-10,24-25H2,1-2H3/t11-,14+/m0/s1
Cas2055757-40-7

Technical Data

AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
Quality control

Description

SHP394 is a potent and orally active SHP2 inhibitor (IC50 = 23 nM) with high lipophilic efficiency, improved potency, and enhanced pharmacokinetic properties.

Chemical Structure

193122 - SHP394 | CAS 2055757-40-7

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