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Solithromycin Catalog No : 17011710

Chemical Information

Product NameSolithromycin
Iupac Chemical Name(3aS,4R,7R,9R,10R,11R,13R,15S,15aR)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone 
SynonymsCEM101; CEM101; CEM 101; OP1068; OP1068; OP 1068 
Molecular FormulaC43H65FN6O10 
Molecular Weight845.01 
SmileNC=1C=C(C=CC1)C=1N=NN(C1)CCCCN1C(O[[email protected]]2([[email protected]]1[[email protected]@H](C([[email protected]@H](C[[email protected]@]([[email protected]@H]([[email protected]](C([[email protected]@](C(O[[email protected]@H]2CC)=O)(C)F)=O)C)O[[email protected]@H]2O[[email protected]@H](C[[email protected]@H]([[email protected]]2O)N(C)C)C)(C)OC)C)=O)C)C)=O
InChiKeyIXXFZUPTQVDPPK-QIFQIIIXSA-N
InChiInChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26-,27+,31+,32-,34-,35-,37-,38+,41-,42-,43-/m1/s1
Cas760981-83-7

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Solithromycin, also known as CEM-101 and OP-1068, is a ketolide antibiotic undergoing clinical development for the treatment of community-acquired pneumonia (CAP) and other infections. It is expected to be the first macrolide antibiotic available in intravenous, oral, and pediatric suspension formulations in over 20 years. Solithromycin exhibits excellent in vitro activity against a broad spectrum of Gram-positive respiratory tract pathogens, including macrolide-resistant strains. Solithromycin has activity against a wide variety of pathogens, and further research is being conducted for other infections. 

Chemical Structure

17011710 - Solithromycin | CAS 760981-83-7

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