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Trifluridine Catalog No : 17030614

Chemical Information

Product NameTrifluridine
Iupac Chemical Name1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione. 
SynonymsTrifluridine; FTD ; 5Trifluorothymidine; NSC 529182; NSC 75520; Trifluorothymidine; Viroptic. Trifluorothymidine 2-Deoxy-5-trifluoromethyluridine; Trifluorothymine deoxyriboside 
Molecular FormulaC10H11F3N2O5 
Molecular Weight296.2 
Smilec1c(c(=O)[nH]c(=O)n1[[email protected]]2C[[email protected]@H]([[email protected]](O2)CO)O)C(F)(F)F
InChiKeyVSQQQLOSPVPRAZ-RRKCRQDMSA-N
InChiInChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
Cas70-00-8
MDLMFCD00006534

Technical Data

Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by Monarch Pharmaceuticals, which is wholly owned by King Pharmaceuticals. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing. It is a component of the experimental anti-cancer drug TAS-102. 

Chemical Structure

17030614 - Trifluridine | CAS 70-00-8

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