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UMI-77 Catalog No : 010426

Chemical Information

Product NameUMI-77
Synonyms2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid 
Molecular FormulaC18H14BrNO5S2 
Molecular Weight468.341 
SmileC1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br
InChiKeyWUGANDSUVKXMEC-UHFFFAOYSA-N
InChiInChI=1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22)
Cas518303-20-3

Technical Data

AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

UMI-77 is a novel selective Mcl-1 SMI inhibitor. UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members. 

Chemical Structure

010426 - UMI-77 | CAS 518303-20-3

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