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Ubenimex Catalog No : 17030602

Chemical Information

Product NameUbenimex
Iupac Chemical Name((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-leucine 
SynonymsUbenimex; NK 421; NK-421; NK421; Bestatin; NSC 265489 
Molecular FormulaC16H24N2O4 
Molecular Weight308.378 
SmileN[[email protected]@H]([[email protected]@H](C(=O)N[[email protected]@H](CC(C)C)C(=O)O)O)CC1=CC=CC=C1
InChiKeyVGGGPCQERPFHOB-RDBSUJKOSA-N
InChiInChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
Cas58970-76-6

Technical Data

Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells. 

Chemical Structure

17030602 - Ubenimex | CAS 58970-76-6

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