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VH298 Catalog No : 18581

Chemical Information

Product NameVH298
Iupac Chemical Name(2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
SynonymsVH-298; VH 298; VH298.
Molecular FormulaC27H33N5O4S
Molecular Weight523.652
SmileO=C([[email protected]]1N(C([[email protected]@H](NC(C2(CC2)C#N)=O)C(C)(C)C)=O)C[[email protected]](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
InChiKeyNDVQUNZCNAMROD-RZUBCFFCSA-N
InChiInChI=1S/C27H33N5O4S/c1-16-21(37-15-30-16)18-7-5-17(6-8-18)12-29-23(34)20-11-19(33)13-32(20)24(35)22(26(2,3)4)31-25(36)27(14-28)9-10-27/h5-8,15,19-20,22,33H,9-13H2,1-4H3,(H,29,34)(H,31,36)/t19-,20+,22-/m1/s1
Cas2097381-85-4

Technical Data

AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
Quality control

Description

VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism.

Chemical Structure

18581 - VH298  | CAS 2097381-85-4

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