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VLX1570 Catalog No : 611932

Chemical Information

Product NameVLX1570
Iupac Chemical NameVLX1570 
SynonymsVLX 1570; VLX-1570 
Molecular FormulaC23H17F2N3O6 
Molecular Weight469.39 
InChiKey
InChi
Cas1431280-51-1

Technical Data

Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM.

VLX1570 inhibits proteasome deubiqu-itinase activity and induces accumulation of high molecularweight  polyubiquitinated proteins in cells.
Knock-down of USP14 in multiple myeloma cells induces loss of cell viability
VLX1570 induces accumulation of polyubiquitin chains and elicits apoptosis of multiple myeloma cells
VLX1570 induces apoptosis and cell death of MM cells


 

Chemical Structure

611932 - VLX1570 | CAS 1431280-51-1

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